中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (34): 6393-6396.doi: 10.3969/j.issn. 2095-4344.2012.34. 025

• 组织构建综述 tissue construction review • 上一篇    下一篇

生物医用高分子材料的血液相容性研究：抗凝血材料的设计

陈宝林1，王东安2, 3   

  1. 1呼伦贝尔学院科研处，内蒙古自治区呼伦贝尔市，021008；
    2浙江大学高分子科学研究所，浙江省杭州市 310027；
    3Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163  
  • 出版日期:2012-08-19 发布日期:2012-08-19
  • 作者简介:陈宝林，男，1960年生，河北省新城县人，汉族，1983年东北师范大学毕业，教授，主要从事组织工程材料（生物医用高分子材料）的制备及表征方面的研究。

Hemocompatibility of biomedical polymeric materials Design of anticoagulant materials○

Chen Bao-lin1, Wang Dong-an2, 3   

  1. 1Bureau of Scientific Research, Hulunbuir College, Hulunbuir 021008, Inner Mongolia Autonomous Region, China;
    2Institute of Polymer Sciences, Zhejiang University, Hangzhou 310027, Zhejiang Province, China;
    3Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, Tennessee, USA
  • Online:2012-08-19 Published:2012-08-19
  • About author:Chen Bao-lin, Professor, Bureau of Scientific Research, Hulunbuir College, Hulunbuir 021008, Inner Mongolia Autonomous Region, China baolinchenkyc@ sina.com

PDF

448

摘要：

背景：对于植入生物活体内的高分子材料，应具有医用功能性和生物相容性。
目的：论述抗凝血材料的设计及血液相容性高分子材料的凝血机制。
方法：由第一作者检索1953/2011 PubMed数据库及万方数据库文献。检索词为“生物相容性材料，抗凝血材料，生物医用材料，医用高分子材料”。
结果与结论：通常对材料进行表面分子设计，改善表面的亲硫水性、引入带电基团、负载生物活性物质等，以尽量减轻血栓形成来提高材料的血液相容性。然而，表面修饰的方法对血液相容性的改善有限。因此，应用组织工程方法在材料表面原位培养人体内皮细胞使材料内皮化，成为改善血液相容性的重要途径。

关键词: 血液相容性, 材料表面, 抗凝血材料, 生物医用高分子材料, 天然生物材料, 抗凝血性, 生物相容性, 内皮细胞

Abstract:

BACKGROUND: Polymeric materials implanted into organism in vivo should have two basic performances: medical function and biocompatibility.
OBJECTIVE: To review design of anticoagulant materials and clotting mechanism of hemocompatible polymeric materials.
METHODS: A computer-based online search of PubMed database and Wanfang database was performed for articles published from 1953 to 2011 with English key words “biocompatibility, blood compatibility, bio-inert surface, bio-active surface” and Chinese key words “biocompatibility, anticoagulant materials, biomedical materials, medical polymeric materials”.
RESULTS AND CONCLUSION: the material surface is designed to improve surface hydrophilicity and hydrophobicity and to enhance hemocompatibility by reducing thrombosis through introduction of charged groups and bioactive substance. However, effects of surface modification to improve hemocompatibility are limited. Tissue engineering technique enables in situ culture of human endothelial cells on material surface to endothelialize the materials and improve hemocompatibility.

中图分类号: